The toxin injection can relieve spasticity symptoms, including hyperhidrosis and movement disorder. The toxin can have an effect on the muscles for three to five months. The duration of the effect of the toxin depends on many factors.
Spasticity treatment
There have been positive results in several studies with botulinum poison treatments for spasticity. The efficacy of the treatment depends on several factors, including appropriate muscle selection, age, and accompanying therapy. In a phase-III clinical trial, letibotulinumtoxin A was better than placebo. Secondary analyses looked at the number of injections, and effectiveness was defined as a change in physician rating scale of spasticity.
Botulinumtoxin injections generally begin to work within two weeks. The effect of one injection may last up to six months, although the effect wears off after a few months. Several injections may be needed to keep the effect for as long as possible. To maximize the effects of botulinum toxins, patients may need occupational therapy and physical therapy.
Hyperhidrosis Treatment
Botulinumtoxin type A local injections have been shown effective for treating primary hyperhidrosis. The desired effects can be seen up to six times per month. This treatment can be considered a viable option to treat hyperhidrosis axillary. It is reasonably affordable. There are several advantages of this treatment over other treatment options, including safety and a shorter recovery time.
For primary focal hyperhidrosis, symptoms can be difficult to treat. Botulinumtoxin A is injected under skin to block the release acetylcholine, a neurotransmitter which mediates sympathetic nervetransmission in sweat glands. Botulinum Toxin A has shown remarkable results in cases of excessive sweating.
Treatment for movement disorder
The use of Botulinum toxin for movement disorders has recently received positive results in patients with various types of movement disorders, such as focal dystonia and spinal myoclonus. The size and location of affected muscles, along with the method of administration, will determine the effectiveness of the treatment. This article will discuss the usefulness of the medication, its indications, and the research to support it.
Botulinumtoxin is used to treat various movement disorders. It can be used for cervical dystonia or generalized dystonia. Both are caused by overactive neck muscles and generalized dysfunction, which affects all muscle groups. The treatment can also be used for symptoms associated with young-onset Parkinson’s disease like motor fluctuations and dyskinesias. Other uses include the treatment for tremor, disorders such as drooling & constipation.
Safety of botulinum toxin
Botulinumtoxin type A (Botox), a neurotoxin, inhibits acetylcholine formation by inhibiting the docking acetylcholine-vesicles at a cell membrane's inner surface. This prevents acetylcholine preventing it from reaching neuromuscular junctions where it triggers the contraction of muscle fibers. The result of this toxicity is a decrease in muscle tone.
Similar results were obtained using the Vancouver scar scale (VMS), and the visual analogue (VAS). The MD of a scar measured -1.06 (99.5%CI; -1.10–-0.02). In the other study, one botulinum txin treatment caused a 0-mm scarring with no significant differences. The new study is promising but future research will need to consider the effects of different dosages and differences in pre- and post-surgical injections.